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Essential role of glucose transporter GLUT3 for post-implantation embryonic development

22 Oct 2008

Abstract excerpt

Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo. Slc2a3(-/-) morulae and blastocysts developed normally, implanted in vivo, and formed egg-cylinder-stage embryos that appeared normal until day 6.0. At day 6.5, apoptosis was detected in the ectodermal cells of...

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PMID: 18948350
DOI: 10.1677/joe-08-0262

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