Article
A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes.
Genes and immunity - 1 Mar 2009
Magitta N F, Bøe Wolff A S, Johansson S, Skinningsrud B, Lie B A, Myhr K-M, Undlien D E, Joner G, Njølstad P R, Kvien T K, Førre Ø, Knappskog P M, Husebye E S
Abstract excerpt
Variants in the gene encoding NACHT leucine-rich-repeat protein 1 (NALP1), an important molecule in innate immunity, have recently been shown to confer risk for vitiligo and associated autoimmunity. We hypothesized that sequence variants in this gene may be involved in susceptibility to a wider spectrum of autoimmune diseases. Investigating large patient cohorts from six different autoimmune diseases, that is...
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