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Article

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

11 Feb 2021

Abstract excerpt

Abstract Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci ( P < 5 × 10 −8 ). In addition to loci implicated in lymphocyte function and development shared with other...

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PMID: 33574239
DOI: 10.1038/s41467-021-21015-8

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