Article
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
Neurobiology of disease - 1 Nov 2022
Cogo Susanna, Tomkins James E, Vavouraki Nikoleta, Giusti Veronica, Forcellato Federica, Franchin Cinzia, Tessari Isabella, Arrigoni Giorgio, Cendron Laura, Manzoni Claudia, Civiero Laura, Lewis Patrick A, Greggio Elisa
Abstract excerpt
Mutations in SPG11, encoding spatacsin, constitute the major cause of autosomal recessive Hereditary Spastic Paraplegia (HSP) with thinning of the corpus callosum. Previous studies showed that spatacsin orchestrates cellular traffic events through the formation of a coat-like complex and its loss of function results in lysosomal and axonal transport impairments. However, the upstream mechanisms that regulate...
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