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Epigenetic inactivation of the miR-34a in hematological malignancies

29 Jan 2010

Abstract excerpt

miR-34a is a transcriptional target of p53 and implicated in carcinogenesis. We studied the role of miR-34a methylation in a panel of hematological malignancies including acute leukemia [acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)], chronic leukemia [chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML)], multiple myeloma (MM) and non-Hodgkin's lymphoma (NHL). The...

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PMID: 20118199
DOI: 10.1093/carcin/bgq033

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