Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia

22 Feb 2014

Abstract excerpt

BACKGROUND: TP53 mutation/deletion is uncommon in chronic lymphocytic leukemia (CLL). We postulated that components of TP53-centered tumor suppressor network, miR-34b/c, in addition to DAPK1 and miR-34a might be inactivated by DNA hypermethylation. Moreover, we tested if miR-34b/c methylation might correlate with miR-203 or miR-124-1 methylation in CLL. METHODS: miR-34b/c, miR-34a and DAPK1 methylation was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24559316
DOI: 10.1186/1479-5876-12-52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemiaPMID 24559316Read ↗

Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia.Semantic proximity Read ↗

17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulationSemantic proximity Read ↗

miR-34a as part of the resistance network in chronic lymphocytic leukemiaSemantic proximity Read ↗

Epigenetic inactivation of the miR-34a in hematological malignanciesSemantic proximity Read ↗

Epigenetic inactivation of the MIR34B/C in multiple myelomaSemantic proximity Read ↗

Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural MesotheliomaSemantic proximity Read ↗

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemiaSemantic proximity Read ↗

Diffuse large B-cell lymphoma with combinedTP53mutation andMIR34Amethylation: Another “double hit” lymphoma with very poor outcome?Semantic proximity Read ↗

MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes.Semantic proximity Read ↗

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

miR-34b/miR-34c: a regulator of TCL1 expression in 11q− chronic lymphocytic leukaemia?Semantic proximity Read ↗

Association of a MicroRNA/TP53 Feedback Circuitry With Pathogenesis and Outcome of B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.