Article

Genes that cause severe liver disease in children also influence risk and severity of common liver conditions in adults

2025-05-12

Abstract excerpt

<h4>Background and aims</h4> Rare, pathogenic variants can cause severe liver disease, requiring transplantation in childhood, but it is unclear how common variants in the same genes affect adults. Here, we aimed to establish population-level genetic evidence for whether ’monogenic’ diseases are associated with liver injury in adulthood. <h4>Methods</h4> We identified 99 genes where pathological mutations cause...

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Literature Corpus work: 98876f95-eb4e-50be-88d9-92d72053969c
DOI: 10.1101/2025.05.09.25326407

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