v-myb transformation of Xeroderma pigmentosum human fibroblasts: overexpression of the c-Ha-ras oncogene in the transformed cells.

doi:10.1016/0014-4827(91)90266-w

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Article

v-myb transformation of Xeroderma pigmentosum human fibroblasts: overexpression of the c-Ha-ras oncogene in the transformed cells.

Experimental cell research - 1 Oct 1991

Michelin S, Varlet I, Martinerie C, Perbal B, Sarasin A, Suárez H G

Abstract excerpt

Human Xeroderma pigmentosum "normal" fibroblasts AS16 (XP4 VI) were transformed after transfection with a recombinant v-myb clone. In this clone (pKXA 3457) derived from avian myeloblastosis virus (AMV), the expression of the oncogene sequences is driven by the AMV U-5 LTR promoter. The transformed cells (ASKXA), which have integrated a rearranged v-myb oncogene, grow in agar, are not tumorigenic in nude mice,...

Topics

Animals
Avian Myeloblastosis Virus
Cell Line
Cell Transformation, Neoplastic
Chick Embryo
Cloning, Molecular
DNA Repair
DNA Replication
Genes, ras
Humans
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Promoter Regions, Genetic

Repetitive Sequences, Nucleic Acid

Transfection

Ultraviolet Rays

Xeroderma Pigmentosum

Source

Open in PubMed

Identifiers

PMID: 1893942
DOI: 10.1016/0014-4827(91)90266-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1893942-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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