Article
Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.
Behavioural brain research - 23 Sept 2011
Aydin Cigdem, Oztan Ozge, Isgor Ceylan
Abstract excerpt
An outbred rat model of novelty-seeking phenotype has predictive value for the expression of locomotor sensitization to nicotine. When experimentally naïve rats are exposed to a novel environment, some display high rates of locomotor reactivity (HRs, scores ranking at top 1/3rd of the population), whereas some display low rates (LRs, scores ranking at bottom 1/3rd of the population). Basally, HRs display lower...
Topics
- Amygdala
- Animals
- Anxiety
- Benzamides
- CA3 Region, Hippocampal
- Corticosterone
- Corticotropin-Releasing Hormone
- Disease Models, Animal
- Exploratory Behavior
- Interpersonal Relations
- Male
- Motor Activity
- Neuropeptide Y