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Article

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Molecular and cellular biology - 1 Dec 2008

Xu Xin, Vaithiyalingam Sivaraja, Glick Gloria G, Mordes Daniel A, Chazin Walter J, Cortez David

Abstract excerpt

ATR kinase activation requires the recruitment of the ATR-ATRIP and RAD9-HUS1-RAD1 (9-1-1) checkpoint complexes to sites of DNA damage or replication stress. Replication protein A (RPA) bound to single-stranded DNA is at least part of the molecular recognition element that recruits these checkpoi...

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Share to Adaptor Proteins, Signal Transducing
Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

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Share to Enzyme Activation

Share to Replication Protein A

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 18936170
DOI: 10.1128/MCB.01079-08
PMCID: PMC2593429

Genes

ATR
ATRIP
HUS1
MRE11
RAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18936170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.PMID 18936170Read ↗

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