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Purification and characterization of human DNA damage checkpoint Rad complexes

25 Sept 2001

Abstract excerpt

Checkpoint Rad proteins function early in the DNA damage checkpoint signaling cascade to arrest cell cycle progression in response to DNA damage. This checkpoint ensures the transmission of an intact genetic complement to daughter cells. To learn about the damage sensor function of the human checkpoint Rad proteins, we purified a heteropentameric complex composed of hRad17-RFCp36-RFCp37-RFCp38-RFCp40 (hRad17-RFC)...

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PMID: 11572977
DOI: 10.1073/pnas.201373498

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