Article
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2008
Morokuma Junji, Blackiston Douglas, Adams Dany S, Seebohm Guiscard, Trimmer Barry, Levin Michael
Abstract excerpt
Ion transporters, and the resulting voltage gradients and electric fields, have been implicated in embryonic development and regeneration. These biophysical signals are key physiological aspects of the microenvironment that epigenetically regulate stem and tumor cell behavior. Here, we identify a previously unrecognized function for KCNQ1, a potassium channel known to be involved in human Romano-Ward and...
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