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Article

Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk.

Breast cancer research and treatment - 1 Sept 2009

Serrano-Fernández Pablo, Debniak Tadeusz, Górski Bohdan, Bogdanova Natalia, Dörk Thilo, Cybulski Cezary, Huzarski Tomasz, Byrski Tomasz, Gronwald Jacek, Wokołorczyk Dominika, Narod Steven A, Lubiński Jan

Abstract excerpt

We studied the effects of BRCA2 and CHEK2 variants on breast cancer risk in two case-control series from Poland and Belarus. The missense BRCA2 variant T1915M was associated with a significant reduction in breast cancer risk (OR = 0.62; 95% CI 0.49-0.79; P = 0.0007). Modest increases of breast ca...

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Source

Identifiers

PMID: 19030985
DOI: 10.1007/s10549-008-0249-1

Genes

BRCA2
CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19030985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk.PMID 19030985Read ↗

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Association of two mutations in the CHEK2 gene with breast cancer.Semantic proximity Read ↗

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Breast cancer predisposing alleles in Poland.Semantic proximity Read ↗

A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland.Semantic proximity Read ↗

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The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech RepublicSemantic proximity Read ↗

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