Article
Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma.
Allergy and asthma proceedings - 1 Jan 2000
Zeyrek Dost, Demir Esen, Alpman Asude, Ozkinay Ferda, Gulen Figen, Tanac Remziye
Abstract excerpt
Asthma is a complex genetic disease. Genetic and functional characteristics of interleukin (IL)-1 support a role as an asthma locus for the IL-1 family on chromosome 2q12-21. This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511C/T and IL-1 receptor antagonist (IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children. Children were divided into two...
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