Article
[HDMX amplification and high levels of HDMX-S splice variant are correlated with a poor prognosis in soft tissue sarcomas].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2004
Bartel F, Schulz J, Blümke K, Kappler M, Bache M, Schmidt H, Taubert H
Abstract excerpt
The aim of this study was to determine the amplification status of the HDMX gene and the expression of the HDMX mRNA particularly that of the HDMX-S splice variant in soft tissue sarcomas (STS). We show that the HDMX gene is amplified in 27% of STSs, which was associated with a worse prognosis (RR = 2.8, p = 0.03). We have also found that the transcript of the HDMX-S variant was predominant in a subset of (14%)...
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