Article
Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes.
Blood - 31 Mar 2011
Piccaluga Pier Paolo, De Falco Giulia, Kustagi Manjunath, Gazzola Anna, Agostinelli Claudio, Tripodo Claudio, Leucci Eleonora, Onnis Anna, Astolfi Annalisa, Sapienza Maria Rosaria, Bellan Cristiana, Lazzi Stefano, Tumwine Lynnette, Mawanda Michael, Ogwang Martin, Calbi Valeria, Formica Serena, Califano Andrea, Pileri Stefano A, Leoncini Lorenzo
Abstract excerpt
Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a unique molecular entity, distinct from other B-cell malignancies. Indeed, by unsupervised analysis...
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