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Article

Alternative pathways for siroheme synthesis in Klebsiella aerogenes.

Journal of bacteriology - 1 Jan 2001

Kolko M M, Kapetanovich L A, Lawrence J G

Abstract excerpt

Siroheme, the cofactor for sulfite and nitrite reductases, is formed by methylation, oxidation, and iron insertion into the tetrapyrrole uroporphyrinogen III (Uro-III). The CysG protein performs all three steps of siroheme biosynthesis in the enteric bacteria Escherichia coli and Salmonella enterica. In either taxon, cysG mutants cannot reduce sulfite to sulfide and require a source of sulfide or cysteine for...

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Identifiers

PMID: 11114933
DOI: 10.1128/JB.183.1.328-335.2001
PMCID: PMC94882

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