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Cysteine Homeostasis Disturbance in Escherichia coli Caused by Exposure to Ciprofloxacin.

Bulletin of experimental biology and medicine - 1 Apr 2024

Sutormina L V, Bezmaternykh K V, Muzyka N G, Oktyabrsky O N, Smirnova G V

Abstract excerpt

E. coli exposure to ciprofloxacin disturbs cysteine homeostasis; an increase in the intracellular concentration of cysteine is dangerous due to its ability to enhance ROS generation. Unlike wild-type bacteria, in which the cysteine content did not exceed the control level, cells of the gshA mutant lacking glutathione are characterized by increased concentration of intracellular cysteine in proportion to the...

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PMID: 38890214
DOI: 10.1007/s10517-024-06110-2

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