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Article

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1 Sept 1991

Abstract excerpt

A novel Mr 17,000 heparin-binding protein was purified from culture medium conditioned by A431 human epidermoid carcinoma cells. This protein, designated HBp17, was found to bind the heparin-binding peptide growth factors HBGF-1 and HBGF-2 in a noncovalent, reversible manner. In addition HBp17 was found to inhibit the biological activities of both HBGF-1 and HBGF-2. Both the binding and inactivation of HBGF-1 and...

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PMID: 1885605
DOI: 10.1016/s0021-9258(18)55368-0

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