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Article

PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.

British journal of cancer - 21 Oct 2008

Harwood C A, Attard N R, O'Donovan P, Chambers P, Perrett C M, Proby C M, McGregor J M, Karran P

Abstract excerpt

The immunosuppressant azathioprine is used to prevent graft rejection after organ transplantation. To investigate whether azathioprine-associated mutagenesis contributes to the high incidence of skin tumours in organ transplant recipients (OTRs), we analysed PTCH gene mutations in 60 basal cell carcinomas (BCC); 39 from OTRs receiving azathioprine and 21 from individuals never exposed to azathioprine. PTCH was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18854826
DOI: 10.1038/sj.bjc.6604665
PMCID: PMC2570526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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