Article
More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine.
Experimental dermatology - 1 Apr 2008
de Graaf Ymke G L, Rebel Heggert, Elghalbzouri Abdoel, Cramers Patricia, Nellen Ruud G L, Willemze Rein, Bouwes Bavinck Jan Nico, de Gruijl Frank R
Abstract excerpt
Immunosuppressive medication in renal transplant recipients (RTR) strongly increases the risk of cancers on sun-exposed skin. This increased risk was considered an inevitable collateral effect of immunosuppression, because UV-induced carcinomas in mice were found to be highly antigenic. Here, we posed the question whether immunosuppression also increases the frequency of p53-mutant foci ('p53 patches'), putative...
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