Article
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.
Molecular systems biology - 1 Jan 2008
Claus Sandrine P, Tsang Tsz M, Wang Yulan, Cloarec Olivier, Skordi Eleni, Martin François-Pierre, Rezzi Serge, Ross Alastair, Kochhar Sunil, Holmes Elaine, Nicholson Jeremy K
Abstract excerpt
To characterize the impact of gut microbiota on host metabolism, we investigated the multicompartmental metabolic profiles of a conventional mouse strain (C3H/HeJ) (n=5) and its germ-free (GF) equivalent (n=5). We confirm that the microbiome strongly impacts on the metabolism of bile acids through the enterohepatic cycle and gut metabolism (higher levels of phosphocholine and glycine in GF liver and marked higher...
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