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Article

Microbiota alters the metabolome in an age- and sex- dependent manner in mice

11 Mar 2023

Abstract excerpt

Commensal bacteria are major contributors to mammalian metabolism. We used liquid chromatography mass spectrometry to study the metabolomes of germ-free, gnotobiotic, and specific-pathogen-free mice, while also evaluating the influence of age and sex on metabolite profiles. Microbiota modified the metabolome of all body sites and accounted for the highest proportion of variation within the gastrointestinal tract....

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PMID: 36906623
DOI: 10.1038/s41467-023-37055-1

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