Article
Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population.
Human genetics - 1 May 2008
Keene Keith L, Mychaleckyj Josyf C, Smith Shelly G, Leak Tennille S, Perlegas Peter S, Langefeld Carl D, Herrington David M, Freedman Barry I, Rich Stephen S, Bowden Donald W, Sale Michèle M
Abstract excerpt
We previously investigated the estrogen receptor alpha gene (ESR1) as a positional candidate for type 2 diabetes (T2DM), and found evidence for association between the intron 1-intron 2 region of this gene and T2DM and/or nephropathy in an African American (AA) population. Our objective was to comprehensively evaluate variants across the entire ESR1 gene for association in AA with T2DM and end stage renal disease...
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