Article
Genome-wide association studies in cancer.
Human molecular genetics - 15 Oct 2008
Easton Douglas F, Eeles Rosalind A
Abstract excerpt
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that susceptibility to these diseases is polygenic. Many of these loci...
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