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Article

Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin.

Molecular cancer therapeutics - 1 Oct 2008

Peklak-Scott Christina, Smitherman Pamela K, Townsend Alan J, Morrow Charles S

Abstract excerpt

Cells expressing elevated levels of allelic variants of human glutathione S-transferase P1 (GSTP1) and/or efflux transporters, MRP1 or MRP2, were used to evaluate the role of GSTP1-1 in cisplatin resistance. These studies revealed that GSTP1-1 confers low-level resistance (1.4- to 1.7-fold) to cisplatin-induced cytotoxicity in MCF7 cells. However, expression of MRP1 (MCF7 cells) or MRP2 (HepG2 cells) failed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inactivation, Metabolic

Share to JNK Mitogen-Activated Protein Kinases

Share to Multidrug Resistance-Associated Protein 2

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Identifiers

PMID: 18852128
DOI: 10.1158/1535-7163.MCT-08-0250
PMCID: PMC2587032

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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