Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.

Archives of biochemistry and biophysics - 1 Jun 1999

Srivastava S K, Singhal S S, Hu X, Awasthi Y C, Zimniak P, Singh S V

Abstract excerpt

Alkylating agents are extensively used in the treatment of cancer. The clinical usefulness of this class of anticancer drugs, however, is often limited by the emergence of drug-resistant tumor cells. Increased glutathione (GSH) conjugation through catalysis by GSH S-transferases (GSTs) is believed to be an important mechanism in tumor cell resistance to alkylating agents. In the present study, we report that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antineoplastic Agents, Alkylating

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Inactivation, Metabolic

Share to Isoenzymes

Share to Kinetics

Source

Identifiers

PMID: 10334868
DOI: 10.1006/abbi.1999.1217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.PMID 10334868Read ↗

Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.Semantic proximity Read ↗

Catalytic efficiencies of allelic variants of human glutathione S-transferase P1-1 toward carcinogenic anti-diol epoxides of benzo[c]phenanthrene and benzo[g]chrysene.Semantic proximity Read ↗

Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.Semantic proximity Read ↗

Catalytic efficiencies of allelic variants of human glutathione S-transferase Pi in the glutathione conjugation of alpha, beta-unsaturated aldehydes.Semantic proximity Read ↗

Glutathione S-transferase polymorphisms: cancer incidence and therapy.Semantic proximity Read ↗

Cancer drugs, genetic variation and the glutathione-S-transferase gene family.Semantic proximity Read ↗

Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals.Semantic proximity Read ↗

Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons.Semantic proximity Read ↗

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.Semantic proximity Read ↗

Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients.Semantic proximity Read ↗

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.Semantic proximity Read ↗

Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.