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Article

Asparagine synthetase is a predictive biomarker of <scp>l</scp> -asparaginase activity in ovarian cancer cell lines

1 Oct 2008

Abstract excerpt

We recently used RNA interference to show that a negative correlation of L-asparaginase (L-ASP) chemotherapeutic activity with asparagine synthetase (ASNS) expression in the ovarian subset of the NCI-60 cell line panel is causal. To determine whether that relationship would be sustained in a larger, more diverse set of ovarian cell lines, we have now measured ASNS mRNA expression using microarrays and a...

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PMID: 18852115
DOI: 10.1158/1535-7163.mct-08-0589

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