Article
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Molecular cancer therapeutics - 1 Apr 2006
Bussey Kimberly J, Chin Koei, Lababidi Samir, Reimers Mark, Reinhold William C, Kuo Wen-Lin, Gwadry Fuad, Ajay, Kouros-Mehr Hosein, Fridlyand Jane, Jain Ajay, Collins Colin, Nishizuka Satoshi, Tonon Giovanni, Roschke Anna, Gehlhaus Kristen, Kirsch Ilan, Scudiero Dominic A, Gray Joe W, Weinstein John N
Abstract excerpt
Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis and tumor phenotype. We used a panel of 60 human cancer cell lines (the NCI-60) as a model system to identify relationships among DNA copy number, mRNA expression level, and drug sensitivity. For each of 64 cancer-relevant genes, we calculated all 4,096 possible Pearson's correlation coefficients relating DNA copy number...
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