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Article

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.

Neurobiology of aging - 1 Sept 2010

Cluett Christie, Brayne Carol, Clarke Robert, Evans Grimley, Matthews Fiona, Rubinsztein David C, Huppert Felicia, Llewellyn David J, Rice Neil, Henley William, Frayling Timothy M, Murray Anna, Melzer David

Abstract excerpt

A recent genome-wide association (GWA) study of late-onset Alzheimer's disease (LOAD) identified 15 novel single nucleotide polymorphisms (SNPs) independent of ApoE. We hypothesised that variants associated with LOAD are also associated with poor cognitive function in elderly populations. We measured additive associations between the five most strongly associated LOAD SNPs and grouped Mini Mental State...

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Source

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Identifiers

PMID: 18848371
DOI: 10.1016/j.neurobiolaging.2008.08.020
PMCID: PMC2975102

Genes

LMNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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