Short tandem repeats in human exons: a target for disease mutations.

Abstract excerpt

BACKGROUND: In recent years it has been demonstrated that structural variations, such as indels (insertions and deletions), are common throughout the genome, but the implications of structural variations are still not clearly understood. Long tandem repeats (e.g. microsatellites or simple repeats) are known to be hypermutable (indel-rich), but are rare in exons and only occasionally associated with diseases. Here...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Computational Biology
• Share to Databases, Nucleic Acid