Article
Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Jemaa Riadh, Achouri Afef, Kallel Amani, Ben Ali Samir, Mourali Sami, Feki Moncef, Elasmi Monia, Taieb Samah Haj, Sanhaji Haïfa, Omar Souheil, Mechmeche Rachid, Kaabachi Naziha
Abstract excerpt
BACKGROUND: Elevated plasma total homocysteine (tHcy), a risk factor for coronary artery disease (CAD), is due to defects in genes encoding for enzymes involved in tHcy metabolism or from inadequate status of vitamins involved in tHcy disposal. Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by...
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