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The effect of intracerebroventricular allopregnanolone on depressive-like behaviors of rats selectively bred for high and low immobility in the forced swim test.

Physiology & behavior - 1 Oct 2018

Almeida Felipe Borges, Fonseca Alan Rios, Heidrich Núbia, Nin Maurício Schüler, Barros Helena Maria Tannhauser

Abstract excerpt

Depression is a highly incapacitating disorder known to have a multifactorial etiology, including a hereditary genetic background. The neurosteroid allopregnanolone (ALLO) is a positive allosteric modulator of the GABAA receptor and has been shown to have an antidepressant-like effect in animals. This study aimed to assess the behavioral effect of ALLO in animals with different backgrounds of depressive-like...

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PMID: 29906470
DOI: 10.1016/j.physbeh.2018.06.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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