Article
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.
The Journal of pharmacology and experimental therapeutics - 1 Jul 2004
Reddy D S, Castaneda D C, O'Malley B W, Rogawski M A
Abstract excerpt
Many of the biological actions of progesterone are mediated through the progesterone receptor (PR), a nuclear transcription factor. Progesterone is well recognized to protect against seizures in animal models. Although this activity has been attributed to the progesterone metabolite allopregnanolone, a GABAA receptor-modulating neurosteroid with anticonvulsant properties, PRs could also play a role. Here, we used...
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