Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anxiolytic activity of progesterone in progesterone receptor knockout mice.

Neuropharmacology - 1 Jan 2005

Reddy Doodipala S, O'Malley Bert W, Rogawski Michael A

Abstract excerpt

Progesterone is an anxiolytic steroid that could play a role in the regulation of anxiety in women. However, the mechanism by which progesterone decreases anxiety is incompletely understood. Progesterone affects the function of the brain by two distinct mechanisms. Progesterone regulates reproductive behavior by activating intracellular progesterone receptors (PRs). In addition, progesterone is believed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Anxiety
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Dose-Response Relationship, Drug

Share to Maze Learning

Share to Progesterone

Share to Receptors, Progesterone

Source

Identifiers

PMID: 15617723
DOI: 10.1016/j.neuropharm.2004.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anxiolytic activity of progesterone in progesterone receptor knockout mice.PMID 15617723Read ↗

Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.Semantic proximity Read ↗

Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes.Semantic proximity Read ↗

Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice.Semantic proximity Read ↗

Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.Semantic proximity Read ↗

Endocrine defects in mice carrying a null mutation for the progesterone receptor gene.Semantic proximity Read ↗

Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle.Semantic proximity Read ↗

Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety.Semantic proximity Read ↗

Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice.Semantic proximity Read ↗

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.Semantic proximity Read ↗

Reproductive phenotpes of the progesterone receptor null mutant mouse.Semantic proximity Read ↗

Anxiolytic effects and neuroanatomical targets of estrogen receptor-β (ERβ) activation by a selective ERβ agonist in female mice.Semantic proximity Read ↗

Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.