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Article

Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohnʼs disease

6 Oct 2008

Abstract excerpt

BACKGROUND: A frequent complication of Crohn's disease (CD) is the formation of strictures and stenoses. Strictures are characterized by a fibrosis of the bowel wall, induced by abnormal wound healing. Functional changes of colonic lamina propria fibroblasts (CLPF) reflected by increased proliferation and collagen synthesis, increased contractility or reduced migratory potential, indicate a change of the...

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PMID: 18839425
DOI: 10.1002/ibd.20735

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