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Article

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.

The Journal of cell biology - 6 Oct 2008

Degtyarev Michael, De Mazière Ann, Orr Christine, Lin Jie, Lee Brian B, Tien Janet Y, Prior Wei W, van Dijk Suzanne, Wu Hong, Gray Daniel C, Davis David P, Stern Howard M, Murray Lesley J, Hoeflich Klaus P, Klumperman Judith, Friedman Lori S, Lin Kui

Abstract excerpt

Although Akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway do not always induce substantial apoptosis. We show that silencing Akt1 alone, or any combination of Akt isoforms, can suppress the growth of tumors established from phosphatase and tens...

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Source

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Identifiers

PMID: 18838554
DOI: 10.1083/jcb.200801099
PMCID: PMC2557046

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18838554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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