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Article

Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.

Cancer biology & therapy - 1 Nov 2012

Dickstein Rian J, Nitti Giovanni, Dinney Colin P, Davies Barry R, Kamat Ashish M, McConkey David J

Abstract excerpt

BACKGROUND: Mutations that activate the PI3K/AKT/mTOR pathway are relatively common in urothelial (bladder) cancers, but how these pathway mutations affect AKT dependency is not known. We characterized the relationship between AKT pathway mutational status and sensitivity to the effects of the se...

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Identifiers

PMID: 22895070
DOI: 10.4161/cbt.21793
PMCID: PMC3493441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22895070-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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