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Article

Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Science signaling - 9 Nov 2010

Fan Qi-Wen, Cheng Christine, Hackett Chris, Feldman Morri, Houseman Benjamin T, Nicolaides Theodore, Haas-Kogan Daphne, James C David, Oakes Scott A, Debnath Jayanta, Shokat Kevan M, Weiss William A

Abstract excerpt

Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and mTOR induce minimal cell death in PTEN (phosphatase and tensin homolog deleted from chromosome 10) mutant glioma. Here, we show that the dual PI3K-mTOR inhibitor PI-103 induces autophagy in a form of glioma that is resistant to therapy. Inhibitors of...

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Source

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Identifiers

PMID: 21062993
DOI: 10.1126/scisignal.2001017
PMCID: PMC3001107

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Akt and autophagy cooperate to promote survival of drug-resistant glioma.PMID 21062993Read ↗

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