Article
Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population.
Investigative ophthalmology & visual science - 1 Feb 2009
Nakanishi Hideo, Yamada Ryo, Gotoh Norimoto, Hayashi Hisako, Otani Atsushi, Tsujikawa Akitaka, Yamashiro Kenji, Shimada Noriaki, Ohno-Matsui Kyoko, Mochizuki Manabu, Saito Masaaki, Saito Kuniharu, Iida Tomohiro, Matsuda Fumihiko, Yoshimura Nagahisa
Abstract excerpt
PURPOSE: The collagen type I alpha 1 (COL1A1) gene was recently reported to be associated with high myopia in the Japanese population. To validate this positive association, the tag single-nucleotide polymorphism (tSNP) approach was used. METHODS: Eight tSNPs, including rs2075555 and rs2269336 (previously reported to be high myopia-susceptible SNPs in the Japanese), were selected to tag the linkage disequilibrium...
Read the complete abstract on PubMed