Article
COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.
Investigative ophthalmology & visual science - 1 Sept 2009
Metlapally Ravikanth, Li Yi-Ju, Tran-Viet Khanh-Nhat, Abbott Diana, Czaja Gregory R, Malecaze Francois, Calvas Patrick, Mackey David, Rosenberg Thomas, Paget Sandrine, Zayats Tetyana, Owen Michael J, Guggenheim Jeremy A, Young Terri L
Abstract excerpt
PURPOSE: Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets. METHODS: High-grade myopia was defined as...
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