Article
A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol.
Diabetologia - 1 Oct 2001
Rosmond R, Chagnon M, Bouchard C, Björntorp P
Abstract excerpt
AIMS/HYPOTHESIS: The melanocortin-4 receptor (MC4-R) regulates food intake and possibly energy expenditure, and the inactivation of the MC4-R by gene targeting results in obesity, a phenotype strongly associated with Type II (non-insulin-dependent) diabetes mellitus. In our study, we addressed the hypothesis that a G-->A substitution at codon 103 (Val-103Ile) of the MC4R gene influences abdominal obesity,...
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