Article
Adhesive substrate-modulation of adaptive immune responses.
Biomaterials - 1 Dec 2008
Acharya Abhinav P, Dolgova Natalia V, Clare-Salzler Michael J, Keselowsky Benjamin G
Abstract excerpt
While it is well-known that adsorbed proteins on implanted biomaterials modulate inflammatory responses, modulation of dendritic cells (DCs) via adhesion-dependent signaling has only been begun to be characterized. In this work, we demonstrate that adhesive substrates elicit differential DC maturation and adaptive immune responses. We find that adhesive substrates support similar levels of DC adhesion and...
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