Article
Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2009
Merino Gracia, Real Rebeca, Baro Marta F, Gonzalez-Lobato Lucia, Prieto Julio G, Alvarez Ana I, Marques Margarita M
Abstract excerpt
ATP-binding cassette transporter ABCG2 [breast cancer resistance protein (BCRP)] is a member of the ABC transporter superfamily that actively extrudes xenotoxins from cells and is a major determinant of the bioavailability of many compounds. ABCG2 expression is strongly induced during lactation in the mammary gland and is related to the active secretion of drugs into the milk. The presence of drug residues and...
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