Article
The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2013
Otero Jon A, Real Rebeca, de la Fuente Álvaro, Prieto Julio G, Marqués Margarita, Álvarez Ana I, Merino Gracia
Abstract excerpt
The bovine adenosine triphosphate-binding cassette transporter G2 (ABCG2/breast cancer resistance protein) polymorphism Tyr581Ser (Y581S) has recently been shown to increase in vitro transepithelial transport of antibiotics. Since this transporter has been extensively related to the active secretion of drugs into milk, the potential in vivo effect of this polymorphism on secretion of xenobiotics in livestock...
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