Evolution and selection of human leukocyte antigen alleles by Plasmodium falciparum infection.

doi:10.1016/j.humimm.2008.08.294

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Article

Evolution and selection of human leukocyte antigen alleles by Plasmodium falciparum infection.

Human immunology - 1 Dec 2008

Ghosh Kanjaksha

Abstract excerpt

Infection by Plasmodium falciparum malaria was one of the major driving forces for the selection of various genes, some of which might be involved in protection against this infection. The human leukocyte antigen (HLA) system is a highly polymorphic supergene complex with extensive diversity across different populations. In areas traditionally endemic for malaria for centuries, there seems to be some selection of...

Topics

Africa, Western
Animals
Antibodies, Protozoan
Evolution, Molecular
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens
Host-Parasite Interactions
Humans
Immunity, Innate
India
Malaria, Falciparum
Plasmodium falciparum
Polymorphism, Genetic
Population Groups
Prevalence
Protozoan Proteins
Severity of Illness Index

Source

Open in PubMed

Identifiers

PMID: 18824049
DOI: 10.1016/j.humimm.2008.08.294

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