Article
Association of malaria parasite population structure, HLA, and immunological antagonism.
Science (New York, N.Y.) - 20 Feb 1998
Gilbert S C, Plebanski M, Gupta S, Morris J, Cox M, Aidoo M, Kwiatkowski D, Greenwood B M, Whittle H C, Hill A V
Abstract excerpt
Host-parasite coevolution has been likened to a molecular arms race, with particular parasite genes evolving to evade specific host defenses. Study of the variants of an antigenic epitope of Plasmodium falciparum that induces a cytotoxic T cell response supports this view. In African children with malaria, the variants present are influenced by the presence of a human leukocyte antigen (HLA) type that restricts...
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