Article
Association of malaria parasite population structure, HLA, and immunological antagonism.
Science (New York, N.Y.) - 20 Feb 1998
Gilbert S C, Plebanski M, Gupta S, Morris J, Cox M, Aidoo M, Kwiatkowski D, Greenwood B M, Whittle H C, Hill A V
Abstract excerpt
Host-parasite coevolution has been likened to a molecular arms race, with particular parasite genes evolving to evade specific host defenses. Study of the variants of an antigenic epitope of Plasmodium falciparum that induces a cytotoxic T cell response supports this view. In African children wit...
Topics
- Alleles
- Animals
- Antigens, Protozoan
- Biological Evolution
- Child
- Epitopes
- Evolution, Molecular
- Gambia
- Genes, Protozoan
- Genetic Variation
- HLA-B35 Antigen
- Humans
- Ligands
- Malaria, Falciparum
- Models, Biological
- Plasmodium falciparum
- Protozoan Proteins
- T-Lymphocytes, Cytotoxic