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NS4B and NS5 mutations expand the temperature range permissive for the replication of dual-host affiliated insect-specific flaviviruses in mosquito cells.

Archives of virology - 26 Feb 2026

Kobayashi Hiroko, Tabata Koshiro, Sasaki Michihito, Hall William W, Sawa Hirofumi, Orba Yasuko

Abstract excerpt

The genus Orthoflavivirus within the family Flaviviridae includes mosquito-borne flaviviruses (MBFs) and dual-host affiliated insect-specific flaviviruses (dISFs). MBFs infect both vertebrates and mosquitoes, while dISFs are thought to infect only mosquitoes, despite their phylogenetic proximity to MBFs. Some dISFs have been shown to be capable of infecting mammalian cells in the setting of a suppressed immune...

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Identifiers

PMID: 41741712
DOI: 10.1007/s00705-026-06584-7
PMCID: PMC12935797

Genes

C6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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