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Transgene Expression of Green Fluorescent Protein and Germ Line Transmission in Cloned Pigs Derived from <i>In Vitro</i> Transfected Adult Fibroblasts

29 Sept 2008

Abstract excerpt

The pig represents the xenogeneic donor of choice for future organ transplantation in humans for anatomical and physiological reasons. However, to bypass several immunological barriers, strong and stable human genes expression must occur in the pig's organs. In this study we created transgenic pigs using in vitro transfection of cultured cells combined with somatic cell nuclear transfer (SCNT) to evaluate the...

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PMID: 18823265
DOI: 10.1089/clo.2008.0036

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