Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities.

doi:10.1002/prot.340100307

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Article

Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities.

Proteins - 1 Jan 1991

Lüthy R, McLachlan A D, Eisenberg D

Abstract excerpt

The profile method, for detecting distantly related proteins by sequence comparison, has been extended to incorporate secondary structure information from known X-ray structures. The sequence of a known structure is aligned to sequences of other members of a given folding class. From the known st...

Topics

Amino Acid Sequence
Artificial Intelligence
Databases, Factual
Mathematical Computing
Molecular Sequence Data
Mutation
Protein Conformation
Sequence Alignment
Solvents

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